O10 Myocardial tolerance to exsanguination and retrieval using whole blood-selective aortic arch perfusion

Abstract Introduction Exsanguination cardiac arrest is the leading preventable cause of death in trauma. Treatment modalities are limited, and prognosis remains dismal. Selective aortic arch perfusion (SAAP) an emerging endovascular resuscitation technique consisting occlusion coronary cerebral circulation with oxygenated fluid. Translational research has demonstrated promising outcomes; however, little known about duration beyond which myocardium cannot be resuscitated. The aims this study to assess myocardial tolerance exsanguination before successful return spontaneous (ROSC) following SAAP, 1-hour survival. Method 23 male adult swine were anaesthetised instrumented. Controlled hemorrhage was performed until defined by MAP <20 mmHg. Animals randomized into 3 groups: 5, 10 15 minutes SAAP. Following ROSC animals observed for 60 minutes. Result Baseline characteristics similar between groups (P > 0.05). 100% (8/8) 5 min group, 75% (6/8) 43% (3/7) 10- 15-min respectively = 0.042). survival 75%, 50% 14% 5-, 0.015). survivors group required less noradrenaline 23.6 (±7.4) compared other 40.9 (±25.8), 0.008). Conclusion effective resuscitative tool eliciting a model lasting >5 min. Sustainable resuscitability using SAAP declines after arrest. Take-home Message outcomes may segway Extracorporeal life support. time limit lies somewhere start